ISMRBF (Erice, Italy)

Invited talk at the “International School of Magnetic Resonance and Brain Function – INVESTIGATING BRAIN FUNCTION AND STRUCTURE BY MAGNETIC RESONANCE AND COMPATIBLE APPROACHES”, 13th Workshop, Erice, Sicily, Italy, 22-29 Aprile, 2018. …

Brain energetics during the sleep-wake cycle

Mauro DiNuzzo, Maiken Nedergaard

Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. …

Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice

Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna L. Xavier, Sofie Christensen, Blanca Aldana, Lasse K. Bak, Ursula Sonnewald, Arne Schousboe, Helle S. Waagepetersen, Maiken Nedergaard

PURPOSE: To investigate brain metabolism using intracisternal delivery of [U-13C]glucose, thus bypassing blood-brain barrier and avoiding effects of peripheral metabolism. …

Not Only Food For Thought

Mauro DiNuzzo

Besides energy, what else does the brain need to function? Probably the way energy is allocated under the control of multiple trade-offs that ultimately shape optimal energy utilization and behavior. …

Temporal Information Entropy of the Blood-Oxygenation Level-Dependent Signals Increases in the Activated Human Primary Visual Cortex

Mauro DiNuzzo, Daniele Mascali, Marta Moraschi, Giorgia Bussu, Bruno Maraviglia, Silvia Mangia, Federico Giove

Time-domain analysis of blood-oxygenation level-dependent (BOLD) signals allows the identification of clusters of voxels responding to photic stimulation in primary visual cortex (V1). …

Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness

Gulin Oz, Mauro DiNuzzo, Anjali Kumar, Amir Moheet, Ameer Khowaja, Kristine Kubisiak, Lynn E. Eberly, Elizabeth R. Seaquist

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia-associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. …

Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K+ Rather than Glutamate

Mauro DiNuzzo, Federico Giove, Bruno Maraviglia, Silvia Mangia

Brain activity involves essential functional and metabolic interactions between neurons and astrocytes. The importance of astrocytic functions to neuronal signaling is supported by many experiments reporting high rates of energy consumption and oxidative metabolism in these glial cells. …