Intracisternal injection of [U-13C]glucose for investigating brain metabolism in freely moving mice

Mauro DiNuzzo, Simon Sanggaard, Serhii Kostrikov, Anna L. Xavier, Sofie Christensen, Blanca Aldana, Lasse K. Bak, Ursula Sonnewald, Arne Schousboe, Helle S. Waagepetersen, Maiken Nedergaard

PURPOSE: To investigate brain metabolism using intracisternal delivery of [U-13C]glucose, thus bypassing blood-brain barrier and avoiding effects of peripheral metabolism. …