Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness

Gulin Oz, Mauro DiNuzzo, Anjali Kumar, Amir Moheet, Ameer Khowaja, Kristine Kubisiak, Lynn E. Eberly, Elizabeth R. Seaquist

Supercompensated brain glycogen levels may contribute to the development of hypoglycemia-associated autonomic failure (HAAF) following recurrent hypoglycemia (RH) by providing energy for the brain during subsequent periods of hypoglycemia. …